Incorporating new liquid-handling technologies into the drug discovery process has been key to keeping pace with the demands for ever-increasing throughput and lower costs. Systems must be designed to cope with the sheer number of assays and novel chemical entities being developed. Furthermore, the screening process can be costly as the testing of valuable compounds can result in substantial waste. Additionally, manual pipetting techniques can, over time, present health and safety risks. As a result there has been an increasing demand for automated liquid-handling systems, such as the mosquito, an automated nanoliter pipettor from TTP LabTech (www.ttplabtech.com).