dragonfly® crystal

Screen optimisation with dragonfly

dragonfly crystal screen optimiser enables complex crystallisation gradients or optimisation screens to be rapidly and accurately prepared, even with viscous liquids, while eliminating cross-contamination.

Protein crystal optimisation made easy

design remotely and be ready to go in minutes

intuitive screen design and dispense software

robust in use from novices to multi user facilities

simple set-up with no blocking or clogging

reduce stock consumption and maintain integrity

low dead volume, no washing

save time optimising complex crystal hits

fast even at high viscosity

optimum repeatability of plates

recall, refine and repeat screens easily

accuracy and precision, irrespective of liquid class

true positive-displacement pipetting

Any liquid type with no cross-contamination

dragonfly provides the freedom to use any liquid type, regardless of viscosity, without the need for liquid classification. Each disposable pipette works independently to dispense any volume into any well, with no cross-contamination, eliminating the need for tip washing. Screen preparation is quick, and a four-ingredient 96-well gradient plate can be dispensed in less than five minutes.

The perfect pair for protein crystallisation

dragonfly is the ideal system to complement mosquito® in the protein crystallisation workflow. Once the initial crystal ‘hits’ are identified, dragonfly optimises the set of conditions to grow better diffracting crystals. Just like mosquito, dragonfly is simple to set up and operate. Only minimal training is needed, so new users can be proficient in less than ten minutes.

Innovation

Bring the benefits of positive displacement pipetting into your lab

dragonfly crystal’s unique nanolitre liquid handling technology enables you to perform ‘traditional’ liquid handling tasks at a fraction of the volume, higher speeds and with lower dead volumes. dragonfly crystal’s disposable positive displacement pipette tips can directly aspirate sample, dispense or multi-dispense and even mix all in nL to mL volumes.
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We're revolutionising liquid handling

Our liquid handling portfolio provides you with accurate and repeatable nanolitre to microlitre pipetting, every time, irrespective of liquid viscosity or environmental conditions.

Built for pure performance


Our liquid handling instruments use innovative technologies within products to provide benefits to researchers.

We produce robust, reliable and easy to use products that overcome difficult technical challenges so that you can focus on solving the scientific ones.

Pipetting technology

Each disposable pipette has its own individual piston, not an air gap or system liquid, offering true positive-displacement pipetting with no risk of cross-contamination.

  • reliable low volume dispensing 
  • no liquid classification or compatibility issues
  • inherently reliable technology
  • no clogging or blocking of nozzles
  • zero cross-contamination
  • enabling efficient assay set up and screening
  • eliminates experimental set-up variation variation

dragonfly crystal tip schematic

Built for pure performance

Non-contact dispensing from a disposable, positive displacement tip. 

In each of the channels (up to 10), there is a tight fitting piston that travels within a pipette barrel. When coupled to the instruments piston rod, the positive displacement syringe is formed. The distance and rates of acceleration and deceleration of the piston control how and when liquid is ejected from the tip.

dragonfly crystal tip

Intuitive by design

Our software is as focused on usability as it is on functionality. We strive for an intuitive user experience that matches the requirements of each scientific application. Through collaboration with scientists, our software team develop and enhance the instrument UI to provide the optimal user experience and facilitate adoption into novel application areas.

dragonfly crystal’s software allows the rapid design and dispensing of highly complex experiments through an intuitive UI that enables you to recall, refine and repeat screens easily. Minimise set-up time and improve the throughput of your dragonfly crystal by designing and simulating complex protein crystallization optimisation screens conveniently at your desktop using offline software.

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dragonfly crystal software

Enhance your protein crystallisation research

Enhance your protein crystallisation screening with MX one - mix any liquid in small wells with no risk of spillage.

The centrifugal forces generated in conventional plate shakers mean that the mixing speed must be limited to avoid liquid spilling from wells. The MX one keeps the plate stationary, allowing for extremely fast mixing of even the most viscous solutions using high-speed oscillation of a disposable pin array.

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MX one

Affordable automation for protein crystallographers

The ultimate lab bundle

Our lab bundle pack is designed to automate your crystallisation drop setting and optimisation whilst meeting increasingly demanding budgets. With over 300 academic publications in two years referencing mosquito, we know how important it is to provide you with productivity and peace of mind in your daily research. You can benefit from unrivalled accuracy and repeatability of across a wide range of viscosities, combined with intuitive software easily mastered by even the most novice user. Three protein crystallisation instruments, two year full warranty and one set of unlimited software licences.
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Technical specifications

Pipetting range
0.5 μL - 4 mL
Throughput
4-6 ingredients in 96-well plate in 4-8 minutes, irrespective of viscosity
Primary SBS plate format
15, 24, 48, 96 and 384
Accessories
MX one in-well mixer, 24 well plate adaptor
Weight
38 kg/ 83.7 lbs (5-head version)
50 kg/ 110 lbs (10-head version)
Dimensions (W x D x H)
575 mm x 600 mm x 645 mm
22.6 in x 23.6 in x 25.3 in
Technical variants
5 or 10 head versions available
What our customers say

What our customers say

The dragonfly has rapidly become an ESSENTIAL tool that significantly streamlines structure determination! Screens that used to take hours to prepare can now be made in under 10 minutes using the user-friendly software and intuitive design of the instrument. Amazingly, the 10-heads are more than sufficient to create screens ranging in complexity from simple x,y gradients to multi-zone optimization. With virtually no dead volume and the fact that you are aliquoting directly into the crystallization tray, the dragonfly can conserve on those expensive chemicals and rapidly produces a crystallization tray ready for the crystallization robot. The dragonfly makes optimization of lead conditions a breeze and alleviates the crystallization bottleneck, allowing you to focus more on the science of the target than on the pursuit of crystals.

Nicholas Noinaj

Purdue University, USA

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