chipCAL: microlitre flow calorimetry for rapid enzyme screening and optimisation
TTP Labtech’s chipCAL, is a low cost, microlitre, flow calorimeter which offers to significantly enhance the enzyme discovery and optimisation process by offering sample run times from only 8 minutes.
Employing TTP Labtech’s innovative flow technology where enzyme and substrate are passed together through a thermodymanic cell simultaneously, chipCAL detects thermodynamic changes using volumes as low as 15 µL, thus reducing reagent and sample usage. This technology provides the additional benefit of non-contact, label free, sample monitoring and its fast throughput enables characterisation of enzyme activity to be achieved within 2-10 minutes per sample. Following analysis, samples are simply passed through to a waste unit and a new sample loaded, often without the need for a laborious wash stage.
chipCAL has the potential to analyse up to 60 samples in an 8 hour working day, thus opening the doors to high throughput enzyme screening.
chipCAL is very easy to use. It has a wide working temperature range of between 15-60°C, allowing a broad range of biological activities to be analysed. It is suitable for the monitoring of a range of processes in the biopharma, food and fermentation industries.
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Download our application note on rapid enzyme activity determination.